V. BhuvaneswariS. SivalingamD. BalajiL. RajeshkumarM. Sathishkumar2025-08-062025-08-062025-09http://doi.org/10.1016/j.rineng.2025.105944https://gnanaganga.alliance.edu.in/handle/123456789/8488Self-healing is the technique to extend the life of any material and is in key demand around the globe. This article focuses on self-healing and self-assembling monomers and polymers as they are used widely in biomedical applications. Sustainable and efficient solutions across industries are offered by self-assembly in conjunction with techniques such as microencapsulation, reversible photo-cross-linking, and the use of composites. Data mining of patents shows an increasing desire to put these ideas to use in the real world, especially in the fields of nanotechnology, energy, and healthcare. The breadth of these innovations can be increased through ongoing multidisciplinary research, which should lead to discoveries that solve global problems. Advanced materials and their biomedical applications will be driven by the future of these technologies' synergy. The current review analyses various synthesis methods of the self-healing and self-assembling monomers and polymers, their biomedical applications, challenges in implementation and envisage these techniques with the aid of patent landscape analysis for predicting the potential growth of these materials over the existing materials and techniques. This review caters the need of materialists to assess the current state and the future directions of self-healing materials in biomedical applications like tissue engineering, bone regeneration and wound healing. © 2025 The Author(s)enBiomedical ApplicationsPatent LandscapeSelf-Assembly MaterialsSelf-Healing Materialsjournal-article