Sahu, VinitaVinitaSahuSharma, PratibhaPratibhaSharmaKumar, AshokAshokKumar2025-03-212025-03-212013Vol. 22, No. 5; pp. 2476-24851054-2523https://doi.org/10.1007/s00044-012-0242-4https://gnanaganga.alliance.edu.in/handle/123456789/4275The present communication deals with the synthesis of a series of 1-[3-methyl-2-(aryldiazenyl)-2H-aziren-2-yl]ethanones. The compounds were synthesized in excellent yields (70-80 %), and the structures were established on the basis of consistent IR, 1H NMR, and elemental analysis data. The purity has been ascertained by chromatographic resolution using hexane-ethyl acetate (6:4 v/v) as binary eluent. All the compounds have been tested for their antimicrobial activity against a representative panel of bacteria i.e., Bacillus subtilis, Escherichia coli, Pseudomonas diminuta, and Staphylococcus aureus using Chloramphenicol as reference drug. All the synthesized compounds were found to exhibit profound antimicrobial activity. © 2012 Springer Science+Business Media New York.1-[3-methyl-2-(aryldiazenyl)-2H- aziren-2-yl]ethanonesMolar refractivityQSARAntibacterialArticle