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Design, synthesis and anticancer evaluation of various aryl thiazole amino quinazoline derivatives as anticancer agents
(Elsevier B.V., 2025)
P, Bala Koteswara Rao (60096612300); Bhansali, Pravin (54400753400); Chollety, Vijay Kumar (59915050900); Nalla, Somaiah (57696421000)
A new series of various aryl thiazole amine incorporated quinazoline (10a-j) derivatives and their structures are characterized by 1HNMR, 13CNMR and mass spectral data. Further, all the newly developed (10a-j) derivatives are assessed for their preliminary anticancer activity against four human cancer cell lines, such as MCF-7(human breast cancer), A549 (human lung cancer), Colo-205 (human colon cancer) & A2780 (human ovarian cancer) by employing the MTT method and etoposide (Etoposide) used as a positive control. Most of the screened compounds were displayed good to moderate activity as compared with etoposide (Etoposide). The IC50 values range from 0.02±0.0072 µM to 7.90±2.14 µM, and the positive control showed values ranging from 0.17 ± 0.034 µM to 3.34 ± 0.152 µM respectively. Among the tested derivatives, five compounds 10a, 10g, 10h, 10i and 10j exhibited more potent activity. Mainly, one compound 10j displayed superior anticancer activity than the positive control. © 2025